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Effects of the microbiome on longevity

Inner Circle Member Forum >> Bowel Flora and Digestive Health >> Effects of the microbiome on longevity


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Join Date: 12/7/2009
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Posted: 9/10/2019 10:46:04 PM

A clinical study on elderly Irish people over the age of 65 found that Bacteroidetes and Firmicutes were the dominant phyla of their microbiota. Bacteroidetes made up 53% of the core microbiota of the elderly compared to 8-27% in younger adults.

Bacteroidetes are gram-negative bacteria that ferment polysaccharides and otherwise indigestible carbohydrates and produce short-chain fatty acids (SCFAs) that have many beneficial effects in the gut. Bacteroides are fat feeders which block inflammation within the body which has a great impact on helping speed up the body’s metabolism. Studies have shown that when there is a higher ratio of Firmicutes within the gastrointestinal tract, that there is a link to obesity.

A double-blind study trialing Lactobacilus acidophilus for six weeks had significant effects on serum insulin, C-reactive protein and uric acid.

A study of supercentenarians aged 105-109 years old were found to have Ruminococcaceae, Lachnospiraceae and Bacteroidacea families. We probably won’t find these species in commercial probiotics yet. Other bacteria associated with slower aging are Bifidobacterium, Akkermansia ,Christensenellaceae, Caprococcus, Faecalibacterium and Roseburia. Chrisensenellaceae is positively associated with improved kidney function.

A study in Japan and a study in China found that long -lived subjects had a greater diversity in their microbiome compared to younger subjects.

Some bacteria make us age faster. These include the group Oscillospira along with subdominant members of the Butyicimonas and Odoribacter order.

E. coli is linked with inflammatory disease, Crohn’s disease, breast cancer, colon cancer and prostate cancer.


Tags: Gut Microbiome ,longevity

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