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Disrupted Galectin-3 causes non-alcoholic fatty liver disease in male mice

Inner Circle Member Forum >> UnKnown >> Disrupted Galectin-3 causes non-alcoholic fatty liver disease in male mice

Heart_Builder

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Posted: 8/31/2011 9:22:15 PM
 
I was wondering if elevated Galectin 3 levels in humans contribute to  non-alcoholic fatty liver disease in humans


But this study seems to say it is Galetin  3 defeicent mice that it increased  (NAFLD) in them. 
I decided to post it anyway and I'll work more on it later.

Thanks all . HB


Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice.
Department of Pathology (I), Faculty of Medicine, University of Toyama, Toyama, Japan.
Galectin-3, a beta-galactoside-binding animal lectin, is a multifunctional protein. Previous studies have suggested that galectin-3 may play an important role in inflammatory responses.
 
Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a liver condition that may progress to end-stage liver disease and based on the known functions of galectin-3, it was hypothesized that galectin-3 might play a role in the development of NAFLD.
 
Thus, this study investigated the role of galectin-3 in NAFLD by comparing galectin-3 knockout (gal3(-/-)) mice and wild-type (gal3(+/+)) mice. The livers of gal3(-/-) male mice at 6 months of age histologically displayed mild to severe fatty change. The liver weight per body weight ratio, serum alanine aminotransferase levels, liver triglyceride levels, and liver lipid peroxide in gal3(-/-) mice were significantly increased compared with those in gal3(+/+) mice.
 
Furthermore, the hepatic protein levels of advanced glycation end-products (AGE), receptor for AGE (RAGE), and peroxisome proliferator-activated receptor gamma (PPARgamma) were increased in gal3(-/-) mice relative to gal3(+/+) mice.
 
In conclusion, this study suggests that the absence of gal3 can cause clinico-pathological features in male mice similar to those of NAFLD. Copyright (c) 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.


http://lib.bioinfo.pl/pmid:17029217
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Heart_Builder

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Posted: 8/31/2011 9:44:00 PM
 
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Posted: 9/1/2011 7:22:28 AM
 
thought - - -is wheat involved with this "critter"??????
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Heart_Builder

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Posted: 9/1/2011 7:18:41 PM
 
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