Cureality Proficiency Certifications and Awards X
Inner Circle Forums


Portions of the Undoctored Inner Circle Member Forum and its vast wealth of knowledge, are available only to our Members.
Becoming an Inner Circle Member will allow you to post topics, ask Dr. Davis questions, and view all replies.


Nicotinamide riboside/sirtulins/longevity

Member Forum >> UnKnown >> Nicotinamide riboside/sirtulins/longevity

lconnolly

No Avatar

Join Date: 9/30/2009
Posts Contributed: 2861
Total Likes: 995
Recommends Recd: 9
Ignores Issued: 0
Certs & Awards: 0   view

Likes Recd: 0
 
Posted: 7/30/2011 3:30:26 PM
 
I find this very interesting. It looks like one of Niacin's main benefits is activating Sirt 1 in the liver.  Therefore it maybe successfully paired with resveratrol.  But perhaps a niacin metabolite, nicotinamide riboside would be even better since it would not cause flushing:

Nicotinamide Riboside: a sirtuin-activating, non-flushing alternative to nicotinic acid?

Another potential route to increased NAD+ synthesis is through the administration of nicotinamide riboside, a recently discovered niacin-related compound in whey that, along with nicotinic acid and niacinamide, is one of the three precursors used in NAD+ salvage metabolism.520

Nicotinamide riboside may offer a better option for improving plasma lipid profiles than nicotinic acid. High dose (≥2 grams) nicotinic acid therapy has long been recognized as an effective means of improving lipid profiles.  Treatment not only reduces levels of triglycerides and low-density lipoprotein cholesterol, but elevates HDL cholesterol—with one glitch—a painful flushing response that typically lasts for ~30 minutes and is so unpleasant that patient compliance becomes a real challenge. Niacinamide does not provoke flushing, but neither does it provide nicotinic acid’s lipid-profile benefits.27

Why does nicotinic acid cause flushing?

Nicotinic acid is an agonist of the G-protein-coupled receptor Gpr109A whose activation in epidermal Langerhans cells is directly responsible for its flushing effect. Fortunately, Gpr109A is not expressed in the liver, so its activation is not responsible for nicotinic acid’s beneficial effects on dyslipidemia. Nicotinic acid’s lipid altering benefits derive from its contribution to increased NAD+ biosynthesis in the liver.20

Why is nicotinic acid, but not niacinamide. effective in improving dyslipidemia?

Nicotinic acid activates Sirt1 in the liver. Sirt 1 deacetylates liver X receptor (LXR), a positive regulator of cholesterol and lipid homeostasis. Niacinamide, at the high doses required to impact dyslipidemia, inhibits sirtuin enzymes (via the mechanism shown above in The Sirtuin Deacetylation Reaction flowchart).

Belenky et al. have suggested that reverse cholesterol transport might be more effectively induced by high-dose niacin (i.e., nicotinic acid given in the range of 2-6 grams) and resveratrol, since both increase sirtuin activity, causing post-translational protein modifications that alter expression of apolipoproteins, transporters, receptors and enzymes involved in lipid metabolism.27 However, nicotinamide riboside might be an even better partner for resveratrol since it increases the availability of NAD+ (and therefore sirtuin activity) without causing flushing.

Tags:

lconnolly

No Avatar

Join Date: 9/30/2009
Posts Contributed: 2861
Total Likes: 995
Recommends Recd: 9
Certs & Awards: 0   view

Likes Recd: 0
 
Posted: 7/30/2011 3:47:11 PM
Back to Top
 
Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!



Tags:

lconnolly

No Avatar

Join Date: 9/30/2009
Posts Contributed: 2861
Total Likes: 995
Recommends Recd: 9
Certs & Awards: 0   view

Likes Recd: 0
 
Posted: 7/30/2011 3:54:51 PM
Back to Top
 
Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!

Tags:

Heart_Builder

No Avatar

Join Date: 11/15/2009
Posts Contributed: 7036
Total Likes: 211
Recommends Recd: 13
Certs & Awards: 39   view

Likes Recd: 0
 
Posted: 7/30/2011 9:32:39 PM
Back to Top
 
Does it raise Blood Glucose Like niacin Lconnolly?
HB


Tags:

lconnolly

No Avatar

Join Date: 9/30/2009
Posts Contributed: 2861
Total Likes: 995
Recommends Recd: 9
Certs & Awards: 0   view

Likes Recd: 0
 
Posted: 7/31/2011 10:18:37 AM
Back to Top
 
Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!

Tags:

lconnolly

No Avatar

Join Date: 9/30/2009
Posts Contributed: 2861
Total Likes: 995
Recommends Recd: 9
Certs & Awards: 0   view

Likes Recd: 0
 
Posted: 7/31/2011 10:30:25 AM
Back to Top
 
So maybe we take resveratrol with our niacin.  Seriously, this may be the way to go.
(And, I  mean a pill of high quality cis resveratrol, not 10 bottles of red wine.  What a flush that would be!  )


Tags:

lconnolly

No Avatar

Join Date: 9/30/2009
Posts Contributed: 2861
Total Likes: 995
Recommends Recd: 9
Certs & Awards: 0   view

Likes Recd: 0
 
Posted: 7/31/2011 10:42:10 AM
Back to Top
 
Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!

Tags:

Heart_Builder

No Avatar

Join Date: 11/15/2009
Posts Contributed: 7036
Total Likes: 211
Recommends Recd: 13
Certs & Awards: 39   view

Likes Recd: 0
 
Posted: 7/31/2011 12:26:09 PM
Back to Top
 
Very Interesting Lconnolly!!!!!!!!!!!!!!!!!!!!!!!
You are getting as bad as me on multiple back to back postings. Thank You for posting this very much.
HB


Tags:

jegesq

No Avatar

Join Date: 7/13/2008
Posts Contributed: 2782
Total Likes: 9
Recommends Recd: 8
Certs & Awards: 0   view

Likes Recd: 0
 
Posted: 8/1/2011 1:51:40 AM
Back to Top
 
Nice.  Very nice.
Tags:

GSH1965

No Avatar

Join Date: 5/1/2019
Posts Contributed: 254
Total Likes: 51
Recommends Recd: 0
Certs & Awards: 0   view

Likes Recd: 0
 
Posted: 8/17/2021 9:40:39 AM
Back to Top
 
Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!



Tags:

Ryan

No Avatar

Join Date: 10/6/2020
Posts Contributed: 446
Total Likes: 42
Recommends Recd: 0
Certs & Awards: 23   view

Likes Recd: 0
 
Posted: 8/17/2021 11:18:40 AM
Back to Top
 
Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!

Tags: