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Lp(a) and Pentoxifylline
Member Forum >> Coronary Disease & Cholesterol Protocol >> Lp(a) and Pentoxifylline

xtronics

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Posted: 10/18/2023 6:51:50 PM
Edited: 10/18/2023 9:44:04 PM (1)
 
Lp(a) is just LDL carrying apolipoprotein(a). Apolipoprotein(a) is genetically derived from fibrogen.

There has been work that shows that Pentoxifylline reduces fibrogen
https://sci-hub.se/10.1097/00001721-199010000-00022

- so one would assume that someone might have researched to see if Pentoxifylline also reduces Lp(a)? I’m not finding it!

Seems DIY trials would be possible. ( Lp(a) tests seem to vary - would take several baseline tests followed by several while taking Pentoxifylline.


Once you realize that CVD is a thrombotic disease and not related to LDL levels, it becomes clear why Lp(a) increases the problem. I consider plaque to be old blood clots paved over with new intima - clots make with apolipoprotein(a) are difficult to resorb.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892136/

I think it is an out of patent drug - so don’t hold your breath waiting for new research.

Also to note:

Elevated insulin => Decreased autophagy => decreased level of degradation of damaged organelles. Postprandial levels of insulin inhibit autophagy completely! Autophagy appears to be related to clot resorption rates. Insulin levels in the obese remain about 10 times those of a normal person even under complete starvation. This would explain why people with T2D (basically insulin tolerance) have more CVD. It also suggests that intermittent fasting might help clear arterial blood clots.
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Bob Niland

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Posted: 10/18/2023 9:43:34 PM
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