Originally posted by Dr. Davis on 2018-07-09
on the Wheat Belly Blog,
sourced from and currently found at: Infinite Health Blog.
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Want to arm wrestle?
I have previously
discussed (in my Undoctored Blog) how loss of
muscle mass is a phenomenon of aging with up to 50%
loss of muscle mass from age 25 to 75,
especially bad if you yo-yo dieted over the years.
We’ve all seen it: Aging involves reduced
ability to climb stairs, hike, wrestle with a shovel,
hoist heavy grocery bags, eventually leading to need
for a cane, walker, wheelchair, or Boy Scout to
assist you in crossing the street. Severe muscle
loss, sarcopenia, is a close cousin of frailty.
Muscle mass has therefore been
labeled a biomarker for biological age.
We need a gauge of biological age because, unlike trees
in which we count rings or measure antler wingspan in
elk, we need a quantifiable measure in humans that we
can track and manipulate.
proving to be a major factor that influences muscle mass:
Any factor that increases your body’s inflammatory
state adds to muscle loss and potentially accelerates
associated phenomena of aging. Among the factors that
consumption–A major contributor to
higher C-reactive protein levels and other inflammatory
markers via gliadin, gliadin-derived peptides, wheat
germ agglutinin, insulin provocation, dysbiotic
changes in bowel flora.
consumption–Via higher insulin levels,
dysbiosis, and, with grains, cultivation of visceral
fat that is a major source of inflammation.
Dysbiosis and small
intestinal bacterial overgrowth–Conversely,
increased Lactobacillus and Bifidobacteria species and prebiotic
fibers reduce inflammation and increase muscle mass,
including reduction in bacterial lipopolysaccharide,
a potent inflammatory mediator produced by organisms
that characterize dysbiosis and SIBO (Enterobacteriaeceae).
Short-chain fatty acid metabolites of bowel
microorganisms, such as butyrate, trigger an increase
in systemic IGF-1 alpha levels that promote
is a byproduct of microbial metabolism with production
amped up by providing prebiotic fibers. Butyrate
administration has been shown to protect against
age-associated muscle loss via an epigenetic mechanism
in addition to its IGF-provoking effect. Notably,
butyrate can also be directly ingested; rich sources
include butter and our L. reuteri
Inflammation is therefore a major
influence over muscle status, along with other factors
such as testosterone, IGF-1 alpha provocation, and
oxytocin. (That last item, oxytocin, by the way, is why
consuming our L. reuteri yogurt is such a
powerful practice: It boosts oxytocin release from the
hypothalamus dramatically, yielding increased muscle,
reduced visceral fat, accelerated healing, increased
bone density, heightened libido, etc.)
Crucial question: If
muscle mass is a biomarker for age, is it simply an
accompaniment or is it causal? If an
accompaniment, like age spots, then increasing muscle
will not yield anti-aging benefits, just as removing age
spots does not make you more youthful. If it is causal,
then increasing muscle mass should yield age-reversing
benefits. However, the jury is still out on whether
increasing muscle is associated with age-reversing effects.
Regardless, increasing muscle
is a good thing. It allows you to remain independent,
less likely to fall and less likely to incur injury
when you do fall, exerts metabolic advantages such as
enhanced insulin sensitivity and protection from
visceral fat accumulation, and improves bone density.
My bet is that increasing muscle mass is not like age
spots and does indeed backpedal on aging to some
degree. In the meantime, by engaging in Undoctored
practices, such as wheat/grain/sugar elimination,
vitamin D restoration, omega-3 supplementation
to mimic primitive eating habits, efforts to
cultivate healthy bowel flora including
L. reuteri seeding, combined with
physical work and/or strength training, I believe
that you have stacked the odds in favor of doing
the tango at age 90 long after your peers
have checked out for the great big breadbasket
in the sky.