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Posted: 3/18/2022 2:07:21 PM
Edited: 6/6/2023 5:03:28 PM (3)
Sourced from: Undoctored Blog,
authored by Dr. Davis, original posting date there: 2018-11-28
PCM forum Index
of Undoctored Blog articles.
Although the original blog content is freely available,
mirroring it here makes it visible to site & forum search
and open for comments.
Undoctored program goals
Let’s focus on some of the program goals that
are achievable in various lab values that reflect metabolic health.
These values reflect the status of your insulin
resistance or sensitivity; the status of fatty liver; markers for
cardiovascular risk; liver health; and thyroid status.
Measures to consider therefore include an NMR
lipoprotein panel (with lipoprotein(a) on the first time this is run);
hemoglobin A1c, fasting glucose, fasting insulin;
25-hydroxy vitamin D; TSH, free T3, free T4, reverse T3,
thyroid antibodies; AST, ALT.
Among the metabolic goals you can aim for are:
- HDL cholesterol of 60 mg/dl or greater—HDL is a
useful index of the quality of your diet and health. Low HDL values of,
say, 42 mg/dl, reflect excess weight, inflammation, high carbohydrate
- Triglycerides of 60 mg/dl or less—Like HDL,
triglycerides are also a useful index of diet and health. When maintained
at or below 60 mg/dl, it means that VLDL particles in the
bloodstream rich in triglycerides are relatively unavailable to
create small LDL particles that lead to heart disease and stroke.
In other words, maintaining triglycerides at this low level (not the
ridiculous 150 mg/dl or conventional guidelines associated with
flagrant quantities of small LDL particles) means that small LDL
particles have been minimized or reduced to zero.
- Small LDL particles of no higher than
200 nmol/L—Though I am most reassured by small
LDL particles of zero, obtained by not consuming the foods that
provoke the formation of small LDL particles: grains and sugars.
(The amylopectin A carbohydrate of wheat and grains are
flagrant triggers of small LDL particles, as they are of postprandial,
or after-meal, rises of VLDL that lead to small LDL.)
- Hemoglobin A1c (HbA1c) of 5.0% or less—Keeping
glycated hemoglobin, i.e., HbA1c, to such low levels tells us that
you have eliminated the huge rise in risk for cardiovascular death
and events from this measure and that you have slowed the process
of aging via glycation of body proteins to a minimum.
- Fasting glucose of 60-90 mg/dl—We want
none of the excess risk for common diseases associated with
insulin resistance and high blood sugars. Blood sugars even
below the pre-diabetic range pose excess risk for such
things as cardiovascular death. We therefore aim for perfect
blood sugars—easily and readily achievable on this lifestyle.
- Fasting insulin of 4.0 mIU/L or less—Low
levels of insulin suggest that insulin sensitivity is restored and
that you need very little insulin to process glucose. Pre-diabetics
and type 2 diabetics typically have values of 30, 50, or
80 mIU/L, sky-high values reflecting insulin resistance. (Just
bear in mind that an occasional person can have a low insulin level
because of pancreatic failure: prior damage to the pancreas from
grain and sugar consumption, glucotoxicity, lipotoxicity, autoimmunity,
and are incapable of making sufficient insulin any more. This applies
to a minority of people. See Wheat Belly Total Health for further explanation.)
- TSH 2.0 mIU/L or less—Along with free T3
and free T4 in the upper half of the reference range. Normalization
of thyroid antibody levels.
- AST/ALT—These liver markers should be kept in the
normal range, markers of liver damage as in fatty liver.
Getting all these values in line is associated
with magnificent health and freedom from hundreds of chronic health
conditions, all achievable on the Undoctored Wild, Naked, Unwashed program.
There are, of course, many other parameters you
can track such as hormonal measures, a wider inflammatory assessment,
PTH and hypothalamic/pituitary assessments, apo E genotype, and many
others. But the above will provide a broad and fairly detailed of the
changes that you experience on the Undoctored Wild, Naked, Unwashed
program. Note what is absent: total and LDL cholesterol, two virtually
useless markers for heart disease risk that should have been abandoned
decades ago except that Big Pharma found a way to turn ignorance into
a pot of gold.
But remember: NEVER have such values drawn if
you are actively losing weight or have lost weight within the past
4 weeks, as the natural process of weight loss introduces
transient distortions due to the mobilization of triglycerides stores
in fat cells. Once weight has plateaued for a minimum of 4 weeks,
then your lab values will truly reflect your metabolic health,
undistorted by the process of weight loss.