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WBB: Modern Wheat: A Terrorist’s Delight

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Posted: 9/25/2012 12:00:00 PM
Edited: 4/30/2022 10:55:30 AM (2)
 

Sourced from: Infinite Health Blog, by Dr. Davis, originally posted on the Wheat Belly Blog: 2012-09-25


Modern Wheat: A Terrorist’s Delight

Modern wheat is the perfect disrupter of bowel health, a creation that even Al Quaeda couldn’t top.

Let’s put aside issues like celiac or gluten-sensitivity triggered by the new gliadin proteins (such as the Glia-alpha9 sequence in most modern wheat), issues that affect 10% of the population. Let’s instead talk about the disruption of bowel health that occurs in EVERYBODY–without the immune activation of celiac or gluten-sensitivity.

In other words, nobody escapes the bowel effects described below. Eat modern wheat and experience the bowel disruption it wreaks, plain and simple.

First, wheat germ agglutinin–indigestible to humans–is a direct intestinal toxin. If 1 mg is fed to a laboratory animal, its intestinal tract undergoes extensive damage not unlike that seen in celiac disease. The average wheat-consuming human takes in 10-20 mg per day.

The direct intestinal destruction of wheat germ agglutinin is made worse by a process first described in 1990 by Dr. Alessio Fasano’s group at Johns Hopkins: The gliadin protein of wheat triggers expression of the zonulin protein in intestinal cells. Zonulin, in turn, disrupts the normal “tight junction” structures (via actin filament polymerization) that provide a normal barrier to foreign substances in the intestinal tract, ordinarily preventing their entry into the deeper tissue layers of the bowel as well as the bloodstream. With the normal tight junction disabled, foreign substances are able to pass between intestinal cells through the impaired tight junction–in short, stuff in your intestine that has no business getting into your bloodstream does. Among the foreign substances allowed access is wheat germ agglutinin.

Fasano 2005--gliadin
Fasano et al 2005

There are three consequences to health as a result of this gliadin-wheat germ agglutinin two-punch effect:

1) Wheat germ agglutinin can enter the bloodstream and hitch a ride to other organs to places like your knees, hips, skin, thyroid gland, eyes, airways and sinuses, resulting in inflammation in those organs: arthritis, rashes, Hashimoto’s thyroiditis, uveitis, asthma and sinus congestion.

2) Gliadin likewise enters the bloodstream and triggers immune phenomena via its “molecular mimicry” effect, its capacity to closely mimic the structure of many human proteins, triggering autoimmune responses: rheumatoid arthritis, lupus, polymyositis, neuropathies, etc.

3) Because the disrupted intestinal lining now acts as a two-way path, water can leak into the intestinal tract, resulting in diarrhea and bowel urgency. In fact, this effect of the gliadin protein has been likened to the effect of cholera toxin that results in intractable watery diarrhea.

Multi-organ inflammation, autoimmunity, and watery bowels: You can see why I often call modern wheat “a perfect chronic poison.” It is as if this thing was specifically designed for maximum damage, an intestinal jihad perpetrated on us by agribusiness mujahideen.


D.D. Infinite Health icon

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