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Uric Acid and Fatty Liver

Inner Circle Member Forum >> Fatty Liver Disease Protocol >> Uric Acid and Fatty Liver

searcher7

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Posted: 5/28/2018 6:26:17 AM
 

Recent studies show that an elevated serum uric acid likely has a direct role to increase fat stores and induce features of metabolic syndrome. Lowering serum uric acid has been found to reduce fatty liver, serum triglycerides, blood pressure and improve insulin resistance in a variety of animal models.

Epidemiological studies show unequivocally that hyperuricemia is a consistent independent risk factor for obesity, fatty liver, insulin resistance and hypertension. Some genetic studies have linked polymorphisms in uric acid transport with hypertension, obesity and metabolic syndrome whereas others have not. Early clinical studies are also suggestive of a benefit of lowering serum uric acid on metabolic syndrome, although larger, randomized studies are needed before any definitive conclusions can be made.

Fructose raises intracellular uric acid, due to the rapid and unchecked phosphorylation of fructose with ATP depletion and consequent degradation of nucleotides. This reaction is driven by fructokinase C, and has a critical role in driving the metabolic phenotype in response to fructose.

I
ntracellular uric acid has an important role in fat accumulation from fructose by causing both direct effects on mitochondria as well as increasing the expression and activity of fructokinase itself .The inhibition of uricase amplifies the effects of fructose to induce insulin resistance, raise blood pressure and increase serum triglycerides in rats.

A recent study showed that subjects with an elevated serum uric acid show a greater ATP depletion in response to fructose.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660463/

Tags: Fatty Liver Disease,Metabolic syndrome,uric acid

Bob Niland

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Posted: 5/28/2018 8:03:26 AM
 
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Heart_Builder

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Posted: 5/28/2018 8:47:43 AM
 
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GDGatz

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Posted: 9/13/2018 7:16:57 PM
 
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Bob Niland

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Posted: 9/13/2018 8:21:14 PM
 
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GDGatz

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Posted: 9/14/2018 5:07:09 AM
Edited: 9/14/2018 5:11:46 AM (1)
 
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Bob Niland

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Posted: 9/14/2018 7:51:50 AM
 
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Posted: 9/14/2018 8:30:45 AM
 
One of the Geritol labels I saw showed 12% alcohol listed after the sugar...


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