Paper (pay-walled) here:
STM: Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Press story here:
ars: Sweet drug clears cholesterol, reverses heart disease—and was found by parents
University press release here:
Uni Bonn: Ring-shaped sugar helps in cases of artherosclerosis
The press release has more useful detail than the ars story (which includes some dumb lipid dogma instead).
Cyclodextrin is a ring sugar already used as a food additive, and presumably
GRAS, so expect a big uptick in your
2-hydroxypropyl-ß-cyclodextrin stock investments, and lots of N=1 experiments.
Since this stuff is not patentable at this point, it's hard
to speculate on what CVD trials might be undertaken.
It does appear that oral ingestion doesn't work - it needs to be IV, which probably explains why nobody stumbled across this effect before.
I haven't seriously dug into this yet, but I'm already wondering if the claimed plaque reversal is soft or calcified. There's also the question of how quickly the reversal works, and whether there's risk of triggering events. This might actually be the rare case of a pay-walled paper worth paying the ransom on.