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Reducing Plaque Progression and Promoting Plaque Stability With Centella asiatica and Pycnogenol

Member Forum >> Coronary Disease & Cholesterol Protocol >> Reducing Plaque Progression and Promoting Plaque Stability With Centella asiatica and Pycnogenol

searcher7

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Posted: 2/10/2016 6:17:30 PM
 
Centella asiatica is an Asian aquatic plant which has triterpenoid molecules that improve the synthesis of collagen. It promotes remodeling of thin-capped , soft plaques into thicker-capped more stable structures that are less likely to rupture.

A study was run with  1,363 subjects aged 45 to 60, who appeared healthy and had no conventional cardiovascular risk factors. All subjects had plaques that did not yet narrow the diameter of the carotid or femoral arteries by more than 50% as seen on ultrasound, and no subjects were experiencing signs or symptoms of cardiovascular disease. All subjects underwent an ultrasound measurement every six months for 30 months in order to determine arterial wall structure and number of plaques that progressed from (class IV) not blocking blood flow to (class V) blocking blood flow.

21.3 % of control patients went from class IV to class V by the end of the study.
5.3% of patients who took 100mg Pycnogenol (extract of maritime pine bark) per day went to class V.
1.1% of patients who took 100mg Pycnogenol plus 100mg Centella asiatica per day went to class V . The risk of plaque progression was 95% lower than in the control group.

Belcaro G, Dugall M, Hosoi M, et al. Pycnogenol and Centella asiatica for asymptomatic atherosclerosis progression. Int Angiol. 2014;33(1):20-6. 

In the same Italian university laboratory, a study was carried out on 824 subjects with more advanced atherosclerosis, namely, with at least one carotid or femoral arterial lesion that extended more than 50% into the arterial wall (class V) but who were, again, without symptoms at the start of the study.Patients were followed up for 42 months.

The following is a breakdown of each group’s percentage of plaques that worsened from class V (meaning symptom-free) to  class VI (those with symptoms), These were not minor symptoms, but rather those of significant loss of blood flow to the brain, such as numbness, tingling, or loss of function on the same side of the brain (for those with carotid artery plaque), or to the leg, such as pain, pallor, or numbness in the leg (for those with femoral artery plaque).

        48% of control subjects   
        10% of Pycnogenol 100 mg alone  
        6.5% of the 100mg Pycnogenol and 100mg Centella asiatica group

Belcaro G, Ippolito E, Dugall M, et al. Pycnogenol and Centella asiatica in the management of asymptomatic atherosclerosis progression. Int Angiol. 2015;34(2):150-7.

These studies on carotid and femoral arteries are interesting. I wonder what the outcome would be on soft plaque in coronary arteries.




 
 
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Pek

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Posted: 2/10/2016 6:40:37 PM
 
I've been taking the life extension arterial protect product which contains centella and pycnogenol


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Bob Niland

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Posted: 2/11/2016 12:12:55 PM
 
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searcher7

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Posted: 2/12/2016 6:23:46 PM
 
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Posted: 2/13/2016 11:22:03 AM
 
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Posted: 2/14/2016 12:36:46 AM
 
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Posted: 2/14/2016 11:03:36 AM
 
Looks like Belcaro is the lead author on almost all of these studies. Wish there was someone else.
But he certainly is giving time and energy to Gotu Kola alone.
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Posted: 10/24/2020 4:53:44 AM
 
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Posted: 10/24/2020 1:10:55 PM
 
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