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New ball game for neuroinflammatory and neurodegenerative diseases

Member Forum >> Bowel Flora and Digestive Health >> New ball game for neuroinflammatory and neurodegenerative diseases

Bob Niland

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Posted: 6/2/2015 10:19:41 PM
Edited: 12/16/2017 7:41:32 AM (1)
 

Nature: Structural and functional features of central nervous system lymphatic vessels

One of the characteristics of the central nervous system is the lack of a classical lymphatic drainage system. Although it is now accepted that the central nervous system undergoes constant immune surveillance that takes place within the meningeal compartment1, 2, 3, the mechanisms governing the entrance and exit of immune cells from the central nervous system remain poorly understood4, 5, 6. In searching for T-cell gateways into and out of the meninges, we discovered functional lymphatic vessels lining the dural sinuses. These structures express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both fluid and immune cells from the cerebrospinal fluid, and are connected to the deep cervical lymph nodes. The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature in the central nervous system. The discovery of the central nervous system lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.

Science Daily is a bit more breathless about it:
Missing link found between brain, immune system; major disease implications
In a stunning discovery that overturns decades of textbook teaching, researchers at the University of Virginia School of Medicine have determined that the brain is directly connected to the immune system by vessels previously thought not to exist.

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Bob Niland

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Posted: 12/16/2017 8:52:12 AM
Edited: 12/16/2017 9:40:50 AM (1)
 
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Bob Niland

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Posted: 3/28/2018 10:49:21 AM
 
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Bob Niland

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Posted: 8/28/2018 7:57:52 PM
 
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Bob Niland

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Posted: 9/15/2018 8:00:33 PM
 
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Bob Niland

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Posted: 9/24/2018 2:13:10 PM
 
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Bob Niland

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Posted: 11/14/2018 11:07:15 AM
 
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lconnolly

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Posted: 11/15/2018 10:35:01 AM
 
Yes Bob, leaky BBB. also leaky mitochondrial outer membrane both well known in functional medicine circles, both poorly understood.


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Bob Niland

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Posted: 1/19/2020 10:19:23 AM
 
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Posted: 1/20/2020 6:40:47 AM
 
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Posted: 1/20/2020 8:08:25 AM
 
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