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Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a Hi

Member Forum >> UnKnown >> Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a Hi

spunk88

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Posted: 5/17/2012 8:11:23 PM
 

Summary

While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night, disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of a HFD for 8 hr per day. Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination. The tRF regimen improved CREB, mTOR, and AMPK pathway function and oscillations of the circadian clock and their target genes' expression. These changes in catabolic and anabolic pathways altered liver metabolome and improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a nonpharmacological strategy against obesity and associated diseases.


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Highlights

? Time-restricted feeding improves clock and nutrient sensor functions ? tRF prevents obesity, diabetes, and liver diseases in mice on a high-fat diet ? Nutrient type and time of feeding determine liver metabolome and nutrient homeostasis ? tRF raises bile acid production and energy expenditure and reduces inflammation

http://www.sciencedirect.com/science/article/pii/S1550413112001891

When you eat matters, not just what you eat

When it comes to weight gain, when you eat might be at least as important as what you eat. That's the conclusion of a study reported in the Cell Press journal Cell Metabolism published early online on May 17th.

When mice on a high-fat diet are restricted to eating for eight hours per day, they eat just as much as those who can eat around the clock, yet they are protected against obesity and other metabolic ills, the new study shows. The discovery suggests that the health consequences of a poor diet might result in part from a mismatch between our body clocks and our eating schedules.

"Every organ has a clock," said lead author of the study Satchidananda Panda of the Salk Institute for Biological Studies. That means there are times that our livers, intestines, muscles, and other organs will work at peak efficiency and other times when they are—more or less—sleeping.

Those metabolic cycles are critical for processes from cholesterol breakdown to glucose production, and they should be primed to turn on when we eat and back off when we don't, or vice versa. When mice or people eat frequently throughout the day and night, it can throw off those normal metabolic cycles.

"When we eat randomly, those genes aren't on completely or off completely," Panda said. The principle is just like it is with sleep and waking, he explained. If we don't sleep well at night, we aren't completely awake during the day, and we work less efficiently as a consequence.

To find out whether restricted feeding alone—without a change in calorie intake—could prevent metabolic disease, Panda's team fed mice either a standard or high-fat diet with one of two types of food access: ad lib feeding or restricted access.

The time-restricted mice on a high-fat diet were protected from the adverse effects of a high-fat diet and showed improvements in their metabolic and physiological rhythms. They gained less weight and suffered less liver damage. The mice also had lower levels of inflammation, among other benefits.

Panda says there is reason to think our eating patterns have changed in recent years, as many people have greater access to food and reasons to stay up into the night, even if just to watch TV. And when people are awake, they tend to snack.

The findings suggest that restricted meal times might be an underappreciated lifestyle change to help people keep off the pounds. At the very least, the new evidence suggests that this is a factor in the obesity epidemic that should be given more careful consideration.

"The focus has been on what people eat," Panda said. "We don't collect data on when people eat.



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jgoldstrich

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Posted: 5/17/2012 9:51:46 PM
 
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canuckchickadee

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Posted: 5/17/2012 10:47:20 PM
 
Makes sense, we have tried having dinner at 4 this past 6 months so not going to bed full. Many countries have their big meal at noon.
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spunk88

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Posted: 5/18/2012 1:53:26 PM
 
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Tyson

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Posted: 5/18/2012 3:34:34 PM
 
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slimjohn

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Posted: 5/18/2012 4:13:06 PM
 

Great post, spunk88!  A 5-star rating!



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Heart_Builder

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Posted: 5/18/2012 6:21:10 PM
 
Wonderful post Stuart
It is awesome. HB
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ptheut

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Posted: 5/18/2012 6:38:07 PM
 
super


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spunk88

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Posted: 5/18/2012 8:02:22 PM
 
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canuckchickadee

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Posted: 5/18/2012 10:43:57 PM
 
breakfast like a king
lunch like a prince
dinner like a pauper


Is that what our gramma;s used to say???


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slimjohn

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Posted: 5/19/2012 12:10:37 AM
 
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canuckchickadee

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Posted: 5/19/2012 6:27:22 AM
 
Exactamount SJ me too:)


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Posted: 7/12/2020 2:46:22 PM
Edited: 7/12/2020 4:36:08 PM (2)
 
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Posted: 7/12/2020 3:20:17 PM
 
I like OMAD or a 5 hour eating window if not fasting. 

Have meal # 1 at 7:00 am and finish meal # 2 before noon.  That’s it. 



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