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Do statins cancel out fish oil and is fish oil more effective than statins in secondary prevention?

Member Forum >> Fish Oil and Omega-3 Fatty Acids >> Do statins cancel out fish oil and is fish oil more effective than statins in secondary prevention?

nsahpt

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Posted: 3/20/2012 10:10:05 PM
Edited: 12/31/2023 11:48:11 AM (1)
 

Hat tip - a tweet from Michael Eades. A very interesting abstract which seems to suggest, inter alia, that in secondary prevention, statins and fish oil may have a: 1+1=1 impact; and fish oil is more effective than statins. I am still trying to obtain the study via my library to make sure this is what the study is saying.


http://eurheartj.oxfordjournals.org/content/early/2012/02/01/eurheartj.ehr499.short

"Effects of n-3 fatty acids on major cardiovascular events in statin users and non-users with a history of myocardial infarction

  1. Daan Kromhout3,*

 

+Author Affiliations

  1. 1Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
  2. 2National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
  3. 3Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
  4. 4Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
  1. *Corresponding author. Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands. Tel: +31 317 483054, Fax: +31 317 483342, Email:daan.kromhout@wur.nl

Abstract

 

Aims Recent secondary prevention trials have failed to demonstrate a beneficial effect of n-3 fatty acids on cardiovascular outcomes, which may be due to the growing use of statins since the mid-1990s. The aim of the present study was to assess whether statins modify the effects of n-3 fatty acids on major adverse cardiovascular events in patients with a history of myocardial infarction (MI).

 

 

Methods and results Patients who participated in the Alpha Omega Trial were divided into consistent statin users (n = 3740) and consistent statin non-users (n = 413). In these two groups of patients, the effects of an additional daily amount of 400 mg eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA), 2 g α-linolenic acid (ALA), or both on major cardiovascular events were evaluated. Multivariable Cox’s proportional hazard models were used to calculate adjusted hazard rate ratios (HRadj). Among the statin users 495 (13%) and among the statin non-users 62 (15%) developed a major cardiovascular event. In statin users, an additional amount of n-3 fatty acids did not reduce cardiovascular events [HRadj 1.02; 95% confidence interval (CI): 0.80, 1.31; P = 0.88]. In statin non-users, however, only 9% of those who received EPA–DHA plus ALA experienced an event compared with 18% in the placebo group (HRadj0.46; 95% CI: 0.21, 1.01; P= 0.051).

 

 

Conclusion In patients with a history of MI who are not treated with statins, low-dose supplementation with n-3 fatty acids may reduce major cardiovascular events. This study suggests that statin treatment modifies the effects of n-3 fatty acids on the incidence of major cardiovascular events."


Moderator note 2023-12-31: basenote date revised as a side effect of getting this "UnKnown" TYP-vintage thread cross-assigned to a suitable Inner Circle forum.

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nsahpt

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Posted: 3/20/2012 11:37:08 PM
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nsahpt

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Posted: 3/21/2012 4:39:07 AM
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Barkeater

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Posted: 3/22/2012 7:45:40 AM
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lconnolly

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Posted: 3/22/2012 9:42:06 AM
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Interesting.
I am intrigued by your remodelling theory NSAHPT. So any variables to remodelling.
It is also dangerous to generalize post MI data to primary prevention.
Thanks for posting.
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Bob Niland

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Posted: 12/31/2023 12:15:59 PM
Edited: 12/31/2023 12:31:07 PM (3)
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