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  rrdueck
  First Post Date: 1/25/2021,   Last Post Date: 1/25/2021
Best practices for long term management of APOE 4/2 and APOE 4/3
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Bob Niland: 
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Posted: 1/25/2021


  SienaF
  First Post Date: 1/25/2021,   Last Post Date: 1/25/2021
My Daughter, who works in the traditional medical world, say...
My Daughter, who works in the traditional medical world, says I should be taking phosphorus with the magnesium Im taking. SHould I add it and what is your brand of choice, if yes

Bob Niland: 
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Posted: 1/25/2021


  R3AL_Man
  First Post Date: 1/25/2021,   Last Post Date: 1/25/2021
My wife has Osteo and inflammatory issues. I’d like her to ...
My wife has Osteo and inflammatory issues. I’d like her to watch a video from Dr. Davis that might inspire a change in her. Something that may reduce her chronic problem. Thanks, Rodger

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Posted: 1/25/2021


  Jibby
  First Post Date: 1/25/2021,   Last Post Date: 1/25/2021
Why does the right side of my body feel cold when i wake up....
Why does the right side of my body feel cold when i wake up. I did have a little issue with my shoulder. A lil pain. Could it be related to that or should i dig deeper for the cause.

Jibby: Its always the right side..usually my arm stomach and back on the right side
I do sleep more on the right side but last night i slept on my back and still woke up with the right side colder
Posted: 1/25/2021

Bob Niland: 
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Posted: 1/25/2021


  Sylvia
  First Post Date: 1/25/2021,   Last Post Date: 1/25/2021
Autoimmune Diet vs WB
Since November I’ve been on and autoimmune diet prescribed by my functional medicine doctor.  I had a total knee replacement December 16 and that definitely put a wrench in my diet but I’m back on track.   In addition to following my wheat belly way of eating  I have eliminated eggs, dairy, and  nightshades. She gave me a Paleo cookbook but I am not using it because of the high carb foods in the recipes. I am using my wheat belly recipes. There are a lot of AIP compliant recipes. I have a couple more weeks on this AIP diet. I will reintroduce eggs first.  I’m wondering if anyone else has had to do this and how did you do it and what kind of results did you get? I haven’t really noticed any significant changes since I’ve eliminated those autoimmune foods other than bowel regularity And a 7 pound weight loss.   Keep in mind I can’t have any of my yogurts. And my stool test had a very low beneficial bacterial count and contained yeast. I did take an anabiotic, Nystatin, and taking probiotics. It’s not a good probiotic so I will be switching once I have finished them. My suspicion a dairy sensitivity.  
open to any suggestions, help, advice guys.  
thanks
Sylvia

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Posted: 1/25/2021


  dan2341
  First Post Date: 1/25/2021,   Last Post Date: 1/25/2021
Hand Skin Rash
Over a year itchy hand rash has finally found relief by using Vitamin D3 Cream on my hands.  No itching for 5 days now and redness is materially reduced and can use soap again without drying out hand skin causing massive flaking.  



  Boo
  First Post Date: 12/27/2020,   Last Post Date: 1/25/2021

dan2341: I am taking 60 mg per night with no problems.  

Posted: 1/25/2021

Toby Lime: 
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Posted: 1/25/2021

Boo: 
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Posted: 1/24/2021


  Sherrie63
  First Post Date: 5/23/2020,   Last Post Date: 1/25/2021
Magnesium Water Questions
Can’t seem to find MOM without sodium hypochlorite in it, was using Good Sense brand from Amazon, which is now unavailable . Any recommendations for other brands? Kroger’s was mentioned but it does contain sodium hypochlorite. Also , while reading the forum I hear talk of possible undeclared calcium in the ingredients, what?!? That’s really the last thing I want to supplement. Can anyone give me more information on this? 

Bob Niland: 
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Posted: 1/25/2021

GSH1965: 
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Posted: 1/25/2021

Bob Niland: 
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Posted: 1/24/2021


  anameth
  First Post Date: 1/25/2021,   Last Post Date: 1/25/2021
Lp(a) results

Just had my Lp(a) tested and it is 76 nmol/l
Since it is elevated, but so close to normal, should i increase my EPA + DHA to 6000 mg, keep it at 3000 mg, or somewhere in between?
Test was drawn after a 12 hour fast.
Thanks, 
Ann

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Posted: 1/25/2021


  Toby Lime
  First Post Date: 1/25/2021,   Last Post Date: 1/25/2021
Your iPhone 12 interferes with your pacemaker...
Your iPhone 12 interferes with your pacemaker

Bob Niland: 
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Posted: 1/25/2021


  Roobinsky
  First Post Date: 1/20/2020,   Last Post Date: 1/25/2021
my thyroid progress
I have had hypothyroidism since a child!  I didn’t start medicine until I was about 20.  All of the women on my maternal side has either hypo or hyper with few exceptions.  I started out on Armour thyroid and did well on the highest dose they produced. Then I was put on Synthroid ( because it was better and easier to manage). I was probably low T3 for a lot of the time based on what I know now.  I was pretty much always symptomatic. Then after reading Undoctored I requested proper thyroid testing.  

My tests showed:

                                2017          2018.         2019

TSH.                          .04.            5.66.         0.11

FT3.                           1.54.          1.83.          2.8

Free T4.                      1.54.           0.6.          1.0


My present meds are levothyoxine 112mc and liothyronine 10 mcg. I have started kelp tablets 225 mcg since the last labs were done.

In early 2019 I tried the Armour again and I wasn’t making any progress. I get the present meds at no cost.  

I had to change doctors when I moved in June 2019 and he offered me a referral to an endocrinologist but I didn’t want to change anything at that time.
I need to go back for a follow up visit and I am concerned about the TSH.  I was thinking perhaps lowering the levothyroxine slightly might be a next move.  I would appreciate feedback on possible dose adjustments and also if I should get any other lab tests.  

I did have the antibody titer and it did not indicate Hashimoto’s according to my doctor.  That was in 2017.


Toby Lime: 
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Posted: 1/25/2021

Roobinsky: 
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Posted: 1/25/2021

Roobinsky: 
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Posted: 1/16/2021


  Roobinsky
  First Post Date: 1/18/2021,   Last Post Date: 1/25/2021
Weird appetite changes since clove tea
I have had some intermittent nausea and lack of appetite since the clove tea. Anybody else notice this?

Dr. Davis : 
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Posted: 1/25/2021

Roobinsky: 
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Posted: 1/25/2021

Roobinsky: Thank you. I wasn’t sure whether to just struggle through it or ease up a little. 
Posted: 1/19/2021


  SteveM
  First Post Date: 1/24/2021,   Last Post Date: 1/24/2021
Fermented yogurt with Lactobacillus helveticus and Bifidobacterium longum from Innovixlabs.
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Ryan: This is a yogurt I stopped making personally, but you can keep making from previous batches as many times as you want. The key is keeping the mix as sterile as you can, so that other bacteria don’t get in.
Posted: 1/24/2021

Bob Niland: 
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Posted: 1/24/2021

SteveM: 
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Posted: 1/24/2021


  christinaw
  First Post Date: 8/14/2011,   Last Post Date: 1/24/2021
Anyone know blood self initiate draw lab or doc like Dr. Davis in Minneapolis?
I could only find one lab in MN and it is quite far from Minneapolis

Lori_Miller: What about this place?
https://provisions.health/location-and-hours/
Posted: 1/24/2021

Tiredmommn: I’m near La Crosse WI and it’s a 6 hour round trip just for labs. Mpls or Madison WI for labs. If anyone else has had an alternative in my area please share. Thank you
Posted: 1/24/2021

PomodoroGuy: Thank you so much everyone for this information. I just wish it was easier to find good doctors!
Posted: 1/24/2021


  HeartHawk
  First Post Date: 1/22/2021,   Last Post Date: 1/24/2021
New ’Microbiome Central’ Feature
We have launched the prototype of our new "Microbiome Central" feature.  It is designed to serve as a cross-indexed database of:

1. Bacterial Strains: A compilation of bacterial strains with evidence of effects
2. Strain Effects: The reported effects of specific bacterial strains.
3. Products: Commercially available products that provide specific bacterial strains.
4. Companies: Providers of products that provide specific bacterial strains.

Here is the link to the prototype page:

Microbiome Central

Members may select from drop-down lists associated with the above four categories in order to display information related to the selected strain, effect, product, and company.  Note that the drop-down lists are not additive and that each drop-down selection clears previous selections. 

The Microbiome Central database has been prepopulated with a subset of information for several previously identified bacterial strains, effects, products, and companies.  Use this Forum topic thread to report errors, ask questions, suggest new information to add to the index, or to address any other issues related to this new feature.

Our hope is that Microbiome Central becomes the "go to" resource for improving health, longevity, and youthfulness via the human microbiome!

HH

hopscotch: Thanks for the idea to use MyLink. I forget about it, and turns out I had two gems already linked!
Posted: 1/24/2021

HeartHawk: 
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Posted: 1/23/2021

Ian989: Great idea. Thanks for that!
Posted: 1/23/2021


  GSH1965
  First Post Date: 1/24/2021,   Last Post Date: 1/24/2021
Reversal of atherosclerotic plaque in the brain
This is another Paul Saladino podcast.  This one is with a doctor who uses mri’s to measure liver fat in his patients.  He shows the patients how their liver fat shrinks with various interventions—with LCHF being a primary intervention.  He has an example of reversing what appears to be arterial plaque in the brain.  Very interesting. 

https://youtu.be/UxOib8PVC4o

GSH1965: 
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Posted: 1/24/2021

Bob Niland: 
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Posted: 1/24/2021


  lavender
  First Post Date: 10/11/2020,   Last Post Date: 1/24/2021
GI Effects results
I received my results yesterday. The interpretation at-a-glance shows high methanobrevibacter smithii, pseudoflavonifractor spp., anaerotruncus colihominis, prevotella spp. and low butyrivibrio crossotus. The total fecal fat and long chain fatty acids are also high. Beta-glucuronidase is high. Fecal zonulin family peptide was 339.5, range 22.3-161.1 ng/mL. I’m planning a consultation with the lab, but until I get an appointment, should I order SIBO treatment? The AIRE device always tests normal the first 3 hours after prebiotic challenge. The report does recommend s boulardii and digestive enzymes. I’ve had hashimotos since 1997. Anyone have experience with this test? Recommendations?

Dr. Davis : 
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Posted: 1/24/2021

Bob Niland: 
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Posted: 1/24/2021

lavender: 
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Posted: 1/24/2021


  GSH1965
  First Post Date: 1/24/2021,   Last Post Date: 1/24/2021
Metabolic health is a better predictor of heart disease risk than LDL
Diet Doctor referenced an interesting observational study that included only women from JAMA Cardiology indicating insulin resistance is a better predictor of heart disease than other bio markers. Here is a link to the abstract. 
https://jamanetwork.com/journals/jamacardiology/article-abstract/2775559

From the Diet Doctor article by Brett Scher “...the hazard ratios for risk of developing future heart disease are as follows:

  • Type 2 diabetes: 10.7
  • Metabolic syndrome: 6.0 
  • High blood pressure: 4.5
  • Obesity: 4.3 
  • Smoking: 3.9 

As for blood tests, this study reports a lab measurement for insulin resistance, called the lipoprotein insulin resistance test (LPIR). 

Of the laboratory tests studied as predictors of heart disease, the LPIR had the highest hazard ratio at 6.4. Triglycerides had the next highest hazard ratio at 2.1, then Apo B at 1.8, and finally, LDL cholesterol with the lowest level of [1.4].  [non HDL was 1.6-my cardiologist likes this marker]

These results suggest metabolic markers are more critical for predicting future heart disease than traditional cholesterol measurements like ApoB and LDL...”


Bob Niland: 
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Posted: 1/24/2021


  livemusic
  First Post Date: 1/16/2021,   Last Post Date: 1/24/2021
Triglycerides and also Vit D problem
Triglycerides are way too high and Vit D reading is way too low. Family history is not good. How soon do you think I could get these tested again to determine if changes I will implement are having an affect?

Unrelated complaint:
I initially wrote a much longer post and the web page ate my post. This is not good. The create-a-post page apparently logged me out and I was not aware of it and then when I finished typing and clicked on submit post, being logged out became evident and I found no way to retrieve all that writing I did. FWIW, other forum software I am aware of "saves" any typed verbiage in a create-a-post window; it becomes grayed-out but it’s there and becomes "live" once you start typing again.

livemusic: Why the fingertip? Is it there that you can always easily find blood? Is there any brand or type of lance/tip that is less of a wound?
Posted: 1/24/2021

Malcolm: 
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Posted: 1/23/2021

livemusic: 
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Posted: 1/23/2021


  Guest
  First Post Date: 1/24/2021,   Last Post Date: 1/24/2021
Appreciate it for this howling post, I am glad I found this ...
Appreciate it for this howling post, I am glad I found this website on yahoo.


  Rodney D
  First Post Date: 1/22/2021,   Last Post Date: 1/23/2021
Too much of a good thing becomes bad thing...yes?

Its hard to believe what some folks will do with a little information. 

<yt-formatted-string>A Man Ate 100 Zinc Vitamin C Gummies Everyday. This Is What Happened To His Spinal Cord.</yt-formatted-string>


Lori_Miller: 
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Posted: 1/23/2021

Ian989: 
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Posted: 1/23/2021

Lori_Miller: Where’s the video called "Dad goes in for a checkup, ends up with dementia from statins"?
Posted: 1/22/2021


  Ryan
  First Post Date: 1/22/2021,   Last Post Date: 1/23/2021
Bio-Cocktail
Can we curate bacterial species in filtered water mixed with pre-biotics? I am not sure how the result will taste like, or will even be drinkable, but specially for the sensitive people to dairy it would be useful to consider.
Has anyone ever tried this?

Ryan: 
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Posted: 1/23/2021

Bob Niland: 
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Posted: 1/23/2021

Ryan: 
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Posted: 1/23/2021


  Bob Niland
  First Post Date: 12/3/2020,   Last Post Date: 1/23/2021
2020-12-09 (***Wed***) 7:00PM CST Vmeet thread
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KathyBrown: 
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Posted: 1/23/2021

HeartHawk: The recording of the opening comments and Q&A for this Meetup is available online at:

2020-12-09 Meetup Q&A
Posted: 12/13/2020

Dr. Davis : 
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Posted: 12/12/2020


  Ian989
  First Post Date: 1/20/2021,   Last Post Date: 1/23/2021
Paul Saladino cautions us against the hazards of coffee
https://www.youtube.com/watch?v=5RkNtzvHXkk&ab_channel=PaulSaladino%2CMD

Key points discussed:

-Coffee contains acrylamide (a neurotoxin and potential carcinogen)
-May worsen certain chronic conditions by binding to opioid receptors
-Contains mycotoxins, aflatoxins, ochratoxins
-Activates NRF2 in the body but he believes to the contrary that’s actually a bad thing with exogenous agents and can be achieved in other ways without collateral damage 


I drink coffee everyday, but only really because I’m addicted and I find it helps my hunger slightly. I think Paul has some good points, although I eat a really healthy diet otherwise so I’m not really concerned if coffee is my one vice. The opioid antagonist point is interesting though. I’ve had chronic lower, left-side back pain for several months now that hasn’t resolved even after doing certain exercises prescribed by my physical therapist. While not severe at all or stopping me from doing any activities, it can flare up sometimes worse and at least reducing my caffeine intake could be an interesting trial to see if it helps

dan2341: Thanks!
Posted: 1/23/2021

Bob Niland: 
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Posted: 1/23/2021

dan2341: 
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Posted: 1/23/2021


  SarahD
  First Post Date: 1/21/2021,   Last Post Date: 1/22/2021
79 years old with blindness and MI
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Bob Niland: 
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Posted: 1/22/2021

livemusic: Anyone... the test in the OP, what type of test shows those values? Doesn’t seem like a common lipid panel.
Posted: 1/22/2021

Dr. Davis : 
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Posted: 1/22/2021


  Bill H
  First Post Date: 1/7/2021,   Last Post Date: 1/22/2021
Colonoscopy soon: will this wreck my gut biome?
I have a colonoscopy coming up, and I’m wondering if the prep solution I have to drink will wreck my gut biome?  And what about the procedure itself with regard to gut biome?  I tried searching on this topic, but the search function is down at the moment. 

Bill

hopscotch: 
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Posted: 1/22/2021

Progutforme: 
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Posted: 1/22/2021

Pek: 
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Posted: 1/22/2021


  Progutforme
  First Post Date: 1/21/2021,   Last Post Date: 1/22/2021
My partner Gary’s hospital medical report says they tried to...
My partner Gary’s hospital medical report says they tried to give him an MRI twice after he arrived in the ER. It said they sedated him twice in 20 minutes. He crawled out of MRI machine 3X.One was done the next day.Are that many MRI’s dangerous?

Dr. Davis : 
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Posted: 1/22/2021

Progutforme: Thank you! Gary does have a metal screw in his ankle which I told the nurse about prior to his MRI.
Posted: 1/21/2021

HeartHawk: 
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Posted: 1/21/2021


  max1001
  First Post Date: 1/22/2021,   Last Post Date: 1/22/2021
Fruits And Vegetables with Lowest Pesticide Loads
https://insteading.com/blog/food-organic-choices/


  Stedman
  First Post Date: 12/4/2020,   Last Post Date: 1/21/2021
Progressing or Regressing?
I entered data from health reports going back four years into the UD ’Health info’ area of the site to help spot trends. Recent test results have been added. With HH’s help I’m able to present the following graphs showing some history. 

I’ve followed Fasting, LCHF then UD protocols during last two years. I took myself off statins earlier in the year and my Cardiologist recommends a return.  Has he got a point?

My CAC score has increased from 695 to 962 which averages out at 20% pa over two years.

All observations, suggestions and recommendations eagerly sought.


Lori_Miller: 
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Posted: 1/21/2021

Bob Niland: 
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Posted: 1/21/2021

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Posted: 1/21/2021


  Sherrie63
  First Post Date: 1/21/2021,   Last Post Date: 1/21/2021
FOS/Inulin ???
I’m confused, is FOS a type of Inulin? Are there benefits from FOS that Inulin does not have or vice versa, benefits Inulin has that FOS does not have? Should I use both?

Dr. Davis : 
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Posted: 1/21/2021

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Posted: 1/21/2021


  Bob Niland
  First Post Date: 1/14/2021,   Last Post Date: 1/21/2021
2021-01-20 (***Wed***) 7:00PM CST Vmeet thread
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HeartHawk: The recording of the opening comments and Q&A for this Meetup is available online at:

2021-01-20 Meetup Q&A
Posted: 1/21/2021

Dean/Beth: 
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Posted: 1/20/2021

Toby Lime: Dr. Davis,

Are you interested to do conference / talks about promoting the program of Undoctored in some of the resorts ( on the beach) in Panama City Beach?
Posted: 1/20/2021


  xtronics
  First Post Date: 3/22/2020,   Last Post Date: 1/21/2021
Relative risks - Coronavirus
Not understanding the attention gap  ... tell me where I am wrong ..

Corona virus - peek (so far) about 50-deaths/day
Car accidents - about -- 100/day  ( all age groups )
Death due to lead exposure  1095/day ( mostly older )

Lancet paper says something like number one cause of early death could well be lead exposure - low levels matter..

The paper says :

"Although we cannot exclude residual confounding, we estimate that about 400 000 deaths are attributable to lead exposure every year in the USA, of which 250 000 are from cardiovascular disease. Concentrations of lead in blood lower than 5 μg/dL (<0·24 μmol/L) are an important, but largely ignored, risk factor for death in the USA, particularly from cardiovascular disease."

"Our findings suggest that, of 2·3 million deaths every year in the USA, about 400 000 are attributable to lead exposure, an estimate that is about ten times larger than the current one."

So my take is 400,000 deaths a year is more important than the coronavirus by - how do I say this? -- A WHOLE LOT !!!  ...

https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30025-2/fulltext

,.,.,.
Those wanting to reduce their risk might want to consider BG and fattyacids..

http://high-fat-nutrition.blogspot.com/2020/03/ards-and-linoleic-acid.html
http://high-fat-nutrition.blogspot.com/2020/03/cell-surface-oxygen-consumption-4.html

( I have not had influenza after I started low-carb - many many years ago... )
,.,.

Also - might be a link with people taking ace inhibitors and NSAIDs -- too soon to tell (I’ve said before that NSAIDs are not as safe as people think - I would only take a fever reducer if I had a fever over 103.5 - but then I might just do cold compresses..):

https://drmalcolmkendrick.org/2020/03/18/coronavirus-covid-19/

https://drmalcolmkendrick.org/2020/03/22/covid-19-update/


xtronics: 
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  Ashraf
  First Post Date: 1/2/2021,   Last Post Date: 1/21/2021
Comprehensive Stool Analysis Lab Report - Need Help to Understand the Report
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Bob Niland: 
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Ashraf: 
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Dr. Davis : No, no mention of Akkermansia or Verrucomicrobia, Ashraf. 

As we discussed in our Meetup last night, no bowel flora testing service provides everything we need, unfortunately, and have some glaring deficiencies.
Posted: 1/21/2021


  Hugh
  First Post Date: 1/20/2021,   Last Post Date: 1/21/2021
What is the benefit of a dramatic reduction of wheat and sug...
What is the benefit of a dramatic reduction of wheat and sugar but not 100%?

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  Guest
  First Post Date: 1/20/2021,   Last Post Date: 1/21/2021
I hav3 low iron....recommended number is 12-14...I’m 8.4. Iv...
I hav3 low iron....recommended number is 12-14...I’m 8.4. Iv3 been reading about phytates and iron depletion...was doing good on wheat belly a few yrs bk... some unforeseen things helped me fall off wagon...should I just do Wb and see if numbers chan

Dr. Davis : There is NO downside to wheat/grain elimination to assess the effects on hemoglobin/anemia. 

I have witnessed many cases of even profound anemia (not due to blood loss) reverse with wheat/grain elimination. 
Posted: 1/21/2021

Lori_Miller: I take an iron supplement every day. Even though I eat red meat nearly every day and avoid grains, I still need the supplement.
Posted: 1/21/2021

Bob Niland: It would serve you to get back on program anyway, but if the iron stays low, it needs to be explained. There can be an actual medical or physiologic pathology that needs attention.
Posted: 1/21/2021


  Pek
  First Post Date: 1/20/2021,   Last Post Date: 1/21/2021
NanoBac
Forum search is down, so I am wondering if anyone remembers past discussion of Nanobac - being recommended to my by Dr.

Pek: No, I know I can login to both sites, just keep going to cureality out of habit.  Old dog <> new tricks.
Posted: 1/21/2021

Bob Niland: 
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Pek: Thanks I figured out my issue was that instill use cureality.com!! Upgrading to inner circle. Thx
Posted: 1/20/2021


  docmaas
  First Post Date: 1/20/2021,   Last Post Date: 1/21/2021
DHA does not retroconvert to EPA but EPA does to DHA according to this study

Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but

substantial conversion of EPA to DHA following supplementation: a randomized control trial

https://academic.oup.com/ajcn/article/110/4/823/5519526

I’m not really familiar with the nomenclature and measuring methods but the logic sounds sound and it is a clever way to utilize naturally occurring isotopes to show conversions paths as opposed to labeling the dha and epa which is what I thought they were doing initially (and if it were would have made it easier to understand but probably more dangerous for the participants.)

In any case it raises the questions of

1  whether the proportions of epa and dha are really important as long as the epa is sufficient and

2  if all those patented epa formulations really maintain their epa identity in the body.  I doubt that conversion to dha was checked for since it was heretofore not believed to occur.


dan2341: No free lunch.   Does the conversion throw off free radicals?  

Posted: 1/21/2021

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  Bob Niland
  First Post Date: 1/20/2021,   Last Post Date: 1/20/2021
2021-01-27 (***Wed***) 7:00PM CST Vmeet thread
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  HeartHawk
  First Post Date: 12/4/2020,   Last Post Date: 1/20/2021
Review and Comparison of Four, PCR-based Stool Test Kits
To All:

As many Members already know from our discussions on the Weekly Live-Video Meetups, I have undertaken a project to review and compare four of the leading providers of PCR-based stool test kits.  The project had two simple goals:

1. Provide physical information about each test (kit contents, collection procedure, cost, strains tested etc.).

2. Compare the results of each test.  Theoretically, because each test uses PCR (actual bacterial DNA), they should all provide similar results.

My process was simple:

1. Order tests kits from from Genova Diagnostics (GI Effects Comprehensive Stool Profile), Diagnostic Solutions Laboratory (GI-Map), Verisana Lab (Gut Health Stool Test), and Viome (Gut Intelligence).

2. Submit samples from a common stool specimen simultaneously collected and submitted as directed in each stool test kit.

Here is a brief graphic and text description of each test kit.

Genova Diagnostics GI Effects Kit

Source: Dr. Kristen Reynolds (available only from registered professionals, had to contact company for provider list).
Price: $359 List, $287.20 Professionals (what I paid), added Zonulin test for additional $64.
Specimen Collection Method: Hand-held tray.
Return Using: Fedex (pre-paid, pre-labeled envelope).
Notes: The only multi-sample (4) test, includes extensive survey on stool specimen, symptoms, diseases, etc.




Diagnostic Solutions GI-Map Kit

Source: Dr. Michele Reyes (available only from registered professionals, had to contact company for provider list)
Price: $359 List, 338.40 Professionals (what I paid), added Zonulin test for additional $64.
Specimen Collection Method: 
Hand-held tray.
Return Using:
 Fedex (pre-paid, pre-labeled envelope)
Notes: None




Viome Gut Intelligence Kit

Source: Ordered online https://www.viome.com/products/gut-intelligence
Price: $149, currently on sale for $129 as of this writing
Specimen Collection Method: 
Toilet-mounted, paper collection strip
Return Using:
 United States Post Office pre-printed label and envelope
Notes: Slick packaging (box in box in sleeve), all online, ordering, kit registration, survey, email progress updates.




Verisana Gut Health Stool Test Kit

Source: Ordered online  through Inner Circle Marketplace
Price: $249.95 List, paid $263.70 ordering through Inner Circle Marketplace
Specimen Collection Method: Toilet-mounted, paper collection strip
Return Using: UPS, must go online to request then print your own label from pdf sent by email.
Notes: Low end packaging



I’ll add more comments as they occur to me, in answer to posted questions, and as results are returned.

HH

Ryan: My guess is they don’t look for everything, and only track certain species. I am waiting for my results from them too, and this will give a good base to compare 
Posted: 1/20/2021

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  Bob Niland
  First Post Date: 3/5/2016,   Last Post Date: 1/20/2021
Stealth Sources of Omega 6 Linoleic Acid
Stealth Sources of Omega 6 Linoleic Acid

Stealth Sources of Omega 6 Linoleic Acid

Edition: 2018-08-26

Introduction

This may be just precautionary fine tuning, or might turn out to be important. In either case, if you’ve decided to take a hard look at your Omega 6 linoleic acid intake (ω6LA hereafter, aka 18:2 ω6 cis,cis-9,12 or n-6), this article might be of some use.

The Undoctored/Wheat Belly program cautions about ω6LA in
OMEGA-6 FATTY ACIDS: TOO MUCH OR TOO LITTLE?
on page 191 of the print edition of Undoctored, which is excerpted in this Wheat Belly Blog post:
How much omega-6 fatty acids do you really need?
“So we don’t want omega-6 overload, but we also don’t want omega-6 deficiency. … Down the road, … you can measure … An ideal omega-6:omega-3 index is 2:1 or less.”
In modern humans, this ratio may be as high as 18:1, thanks to industrial grain and legume oils. The goal is not to drive it to 0:1 or even below 1:1.

Measuring Omega 6:3 ratio (and Omega 3 Index) is probably pointless during weight loss, as the weight being lost is mobilized stored fat, and fat that represents the prior diet, likely high in ω6LA. But the program guidance is clear:
   minimize or eliminate added ω6LA.
You’re going to get ample from nuts, recommended seeds, fish, meats, eggs and some dairy.

The production of industrially refined oils from subsidized grains and legumes has risen dramatically in the past half century. The composition of human fat reflects this, as do waistlines, but the obesity problem has more factors than just vegetable oil.

If you don’t know how much ω6LA you are consuming, you might want to find out. There’s some chance that it’s too much. If following the Undoctored or Wheat Belly program hasn’t delivered all of the health benefits you expected, and everything else has been ruled out, stealth ω6LA may be playing a role, at the very least preventing you from attaining your desired ω6:ω3 ratio. Those familiar with the concerns about ω6LA, and the usual sources of it, can just skip down to Stealth Sources of Excess LA.

The potential hazards of excess ω6LA are for the most part not recent developments. A 1963 paper discusses it, and that may not be the oldest: Plasma Lipid Fatty Acids During Fasting Am J Clin Nutr

A team of investigative scientists has also turned up that two landmark trials used to prop up the early cholesterol hypothesis, in failing (I’m being charitable) to publish their data, hid not just that lower cholesterol correlated to reduced lifespan, but that doing it by replacing saturated fats with polyunsaturated fats high in ω6LA was probably a factor.

Various fatty acids, including the poly-unsaturated (PUFA) ω6LA and ω3s are generally considered “essential”, or an EFA. It is true that humans cannot synthesize the EFAs. But if we are on an LCHF diet, we probably do not need to deliberately attend to getting ample ω6LA. Specifically assuming that more is better would be a serious mistake (and deliberately consuming oils with excess ω6LA has been a key part of government and consensus medicine “low fat” policy over the last several decades).

It is thought that ancestral human intake of ω6:ω3 was in a ratio of near 1:1. The proportion of ω6 doubtless began rising with agriculture (grain seeds are high in ω6), ramped up during the 20th century, and accelerated in the last several decades (due both to dietary policy and due to refining it from subsidized crops). Many populations are now at ω6:ω3 ratios as high as 18:1. The trend line for the production and consumption of industrial seed oils (the majority of the so-called vegetable oils) is a perfect correlate to trends in many chronic non-infectious ailments — this may be no coincidence.

The Potential ω6LA Hazards

I personally consider low-fat mania to be the #3 problem in modern diet, behind #2 (added sugars) and #1 (grains, wheat in particular). The low-fat mania problem itself breaks down into several parts:
• low overall fat consumption,
• groundless saturated fat phobia,
• excess PUFA intake (ω6LA in particular), and
• some residual trans-fat exposure (now in decline, fortunately).

An Undoctored forum user has a useful page about PUFAs, with links to various papers on the conjectured etiologies. It’s also been discussed in this forum, most recently at: How much 18:2 ω-6 linoleic acid do you really want to eat?
There are other pundits tallying the potential issues, such as Tucker Goodrich.

Adverse effects of excess ω6LA may include, but are not limited to:

  • inflammation
  • competes with ω3 where you need it
  • cancer correlations (mitochondrial disruptor?)
  • strongly suspected in CVD
  • may be inherently obesogenic (distorts insulin resistance)
  • strongly suspected in AMD
  • thyroid/liver effects: above a specific ω6LA titer, the liver, in response to thyroxine, decreases beneficial fatty acid synthesis and inhibits glycogen depletion (demonstrated in rodents)

What are the direct effects on important lab tests, such as hsCRP, HDL, LDL-P and Lp(a)? Finding unambiguous data seems unlikely, primarily due to trials confounded by diets uncontrolled for carbohydrate consumption, or not including an arm on a diet anything like what is advocated here. N=1 trials may be the near term alternative (that would be you).

That Transtronics page includes a list of PUFA oils, and their ω6LA content. I consider 15% to be a rough upper limit for an oil suitable for routine use, unless it has a favorable ω6:ω3 ratio, or other redeeming factor(s).

Obvious Sources of ω6LA

The following oils have no place in an Undoctored or Wheat Belly pantry (as oils): Black Cumin Seed, Canola (and Rapeseed), Corn, Cottonseed, Grape Seed, Hemp, Linseed, Peanut, Pistachio, Poppy Seed, Pumpkin Seed, Safflower, Rice Bran, Soybean, Sunflower, Wheat Germ. This is just on the basis of ω6LA content. Some of these oils present additional content issues as well.

Many of the above have further problems due to how they are processed. See the unintentionally notorious How It’s Made video on canola for an example. High temperatures cause oxidation. Chemical solvents can end up as residues. Deodorants may be added, along with BHA and BHT.

Oils that might be OK for light or occasional use are:
Almond, Sesame, Walnut

Some of the above are fine as whole seeds, whole nuts or flours, including almond, hemp, pistachios, pumpkin seeds, sesame seeds, sunflower seeds, walnuts and peanuts (limited).

Recommended oils, that meet or are below my 15%LA cut-off are:
Avocado, Butter (grass-fed), Coconut, Flax, Ghee, Hazelnut, MCT, Olive (if authentic), Macadamia, Palm

Plain Sources of ω6LA

Once attuned to minimizing ω6LA, the following sources are relatively easy to identify and avoid, usually by examining both the Nutrition Facts panel and the Ingredients list:

  • The majority of processed ready-to-eat foods contain oils high in ω6LA, not to mention grains, added sugars, preservatives, emulsifiers, food coloring, flavorants and other junk.
     
  • The majority of condiments contain oils high in ω6LA, including spreads (margarine), salad dressings, mayonnaise, and non-dairy mimic products. Low-fat versions of these may have less or no LA, but may be expected to be high glycemic instead.
     
  • Restaurant meals must be presumed to have been prepared in or with adverse ω6LA oils, unless specifically disclaimed (and price does not protect you on this).
     
  • Cooking sauces and fillings require close examination: tartar, hollandaise, etc. are likely to be soy slimes.
     
  • Supplements in capsule form often contain soybean or other adverse oil.

Nutrition Facts and Ingredients disclosures never call out ω6LA specifically, by the way. Even at Nutritiondata.self.com, their detailed Fats and Fatty Acid breakdowns for foods and products may show the 18:2 content under Polyunsaturated Fat but fail to tell you the name of that (or any of the other fatty acids). So expect little help on avoidance in processed food-like substances.

Stealth Sources of Excess ω6LA

The already-alert ω6LA detective needs to be on the lookout for LA arriving unannounced via:

  • That expensive Italian brand Extra Virgin Olive Oil (EVOO) in your pantry may not actually be EV. It may not even be OO (which means it’s some junk ω6LA with coloring, flavoring, deodorants, and who knows what else). You might want to switch to a California brand, or some other source with credible provenance.
     
  • This olive oil problem applies to any processed food product that purports to contain olive oil. You may safely assume that any major brand product listing olive oil as an ingredient is at some risk of not containing what they want you to think it does. The more prominent the mention of OO, the more likely they think they are pandering to a fad that doesn’t matter, and thus doesn’t merit any real attention to quality control.
     
  • Almost any oil, used for any purpose, in a restaurant meal, is going to be a cheap industrial seed oil. Go for baked or grilled dishes, not fried. Ask for sauces and dressings on the side. As infrequently as I eat at Chipotle, their use of rice bran oil isn’t that great a hazard.
     
  • What passes for “butter” in restaurants, both on the table and in the kitchen, is often a butter/PUFA blend, and may be expected to be CAFO butter as well.
     
  • CAFO meats have a more adverse ω6:ω3 ratio. Curiously, this is not due to higher ω6, but because the ω3 is driven to nil. However, the absolute levels of omegas in muscle meats are so low that this is not a major issue. So avoid CAFO meats, and seek grass-fed pastured (pasture-finished) organic due to second-hand growth hormones, antibiotics, pesticide residues, etc.
     
  • Getting back to using lard or tallow? Make sure it’s grass-fed. In one test, CAFO lard was found to be over 16:1 ω6:3, vs. 1.4:1 for grass-fed. The grass-fed was also lower in natural trans fats. Your bacon needs to be pastured as well.
     

That will cover most situations. If it doesn’t:

  • Don’t go nuts on the nuts. Excessive consumption of even almonds can present an elevated ω6LA exposure.
     
  • If you are eating fish to get ω3 DHA&EPA, make sure you actually get it. Fish, unless a species that cannot be farmed, or credibly claimed to be wild caught, must be presumed to be farmed, and fed the same sort of ω6LA-laden chow that terrestrial critters suffer, which ends up in the fish fat, and adversely increases the ω6:ω3 ratio. Cross tilapia off your menu entirely.
     
  • If you won’t eat CAFO bacon or steak, don’t drink CAFO milk/cream, don’t use CAFO butter, and maybe not eat CAFO cheese. Grain-fed cows produce milk with a much higher ω6:ω3 ratio, unless the cows are getting ω3 supplements, which may be presumed to be ALA, and which probably does nothing to reduce the ω6 content. However, ω6LA content in the milk may be a secondary problem compared to the beta casein A1 issue. rBST frets are further down the list. Again, seek organic, grass-fed, pastured, A2 (goats and sheep are A2).
     
  • If you’re really determined to drive down ω6LA, another common source is chickens, and their eggs. ω3 is not the only nutrient depressed in CAFO eggs. Seek pastured organic eggs. Although chicken and eggs, even pastured organic, have an unfavorable ω6:ω3 ratio, the fat content is also low, so the ω6LA absolute content is low.

ω6LA Reduction Checklist

Omega 3 Index and Omega 6:3 ratio are two tests recommended via the Cureality Dashboard. These provide a baseline for assessing the results of any dietary adjustment. If you are presently loosing weight, these tests might be misleading, as they may be biased toward the profile of fat stores, and not current diet.

Even when weight stabilizes, it may take some time for the Omega tests to reflect eventual status. What you are eating is going in. What’s coming out may have been eaten long ago. The half-life of adipose fat has been conjectured to be as high as 600 days (but this is disputed).

To re-cap, to reduce your exposure to ω6LA, take the following steps:

  • Get ample Omega 3 DHA & EPA. This is normally going to mean supplementing. ω6:3 ratio matters.
  • Stop buying, and discard all of these oils (as refined oils): Black Cumin Seed, Canola (and Rapeseed), Corn, Cottonseed, Grape Seed, Hemp, Linseed, Peanut, Pistachio, Poppy Seed, Pumpkin Seed, Safflower, Rice Bran, Soybean, Sunflower, Wheat Germ.
  • Stop consuming any processed foods that contain the above oils.
  • Major offenders in processed foods are salad dressings (almost all of them), mayonnaises (almost all of them) sauces, dips, etc.
  • Check your capsule supplements for the above oils, and switch to other formulations on re-order.
  • Stop consuming deep-fried restaurant dishes, which may be presumed to have been cooked in, and loaded with, one of the above oils, in a well-oxidized if not rancid form. Think twice about sauteed or otherwise pan-fried.
  • Do not use restaurant butter, unless packaged with credible claims (unlikely).
  • Do a background check on your olive oil. This is likely to result in discarding it, and switching to something with a credible provenance.
  • Seek credibly wild-caught fish, and not packed in oil, as any claim of even olive oil cannot be relied on.
  • Minimize consumption of peanuts, and especially most peanut butters (which have added ω6LA and emulsifiers).
  • If you have any of the following oils (as refined oils), mark them "Use Sparingly": Almond, Sesame, Walnut
  • Seek pasture-raised pasture-finished organic land animal products, including dairy and eggs. If you don’t know, you must assume the source is CAFO, which may be expected to be high in ω6LA, low in ω3, and bear second-hand antibiotics, second-hand hormones, plus pesticide uptake.
  • If Omega blood tests remain unfavorable, consider moderating pork intake, and…
  • On chicken, favor the white meat, which is very low in ω6LA.

___________
Bob Niland [disclosures] [topics] [abbreviations]


docmaas: 
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Rodney D: Wow, what a surprise, can’t trust them to have honest labeling ;>)

I gave up the AO in June and since then only buy Cali evoo in glass bottles. I do eat plenty of avocado’s tho.

Ty Bob
Posted: 1/20/2021


  Ashraf
  First Post Date: 11/27/2020,   Last Post Date: 1/20/2021
Anyway we can get a full recipe for Clove Green tea recipe t...
Anyway we can get a full recipe for Clove Green tea recipe that Dr. Davis mentioned during last meet-up call?

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  Guest
  First Post Date: 1/19/2021,   Last Post Date: 1/20/2021
Calcium score is 1200 what to do ...
Calcium score is 1200 what to do

Pek: Share more detail about yourself to get feedback from others who are also have high calcium scores.
Posted: 1/20/2021

Bob Niland: See the public links under CAC in the Cardiac QR.
Posted: 1/20/2021

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  docmaas
  First Post Date: 1/19/2021,   Last Post Date: 1/20/2021
Anyone else taking monoacylglycerol based fish oil?

Comparison of pharmacokinetics of omega-3 fatty acid supplements in monoacylglycerol or ethyl ester in humans: a randomized controlled trial

https://www.nature.com/articles/s41430-020-00767-4#Tab1

There are also some studies with drosophila (fruit flies) showing life extension with this form of fish oil.  Even with its touted better bioavailability it comes out to be more expensive than other formulations.  What triggered me is that a greater % of the ingested products shows up in the blood and more quickly as well. 



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  Iron Man
  First Post Date: 1/20/2021,   Last Post Date: 1/20/2021
Intestinal bacteria may affect severity of COVID

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  HeartHawk
  First Post Date: 1/17/2021,   Last Post Date: 1/19/2021
Amazon CloudSearch Site Search Implementation
This topic was created to host all discussion related to the Undoctored Inner Circle Site Search feature found at

https://innercircle.undoctored.com/category_search.aspx

The Undoctored Inner Circle Site Search is currently under beta-test development. It employs the Amazon CloudSearch service.  New Forum posts are uploaded to CloudSearch every hour and new site pages are uploaded every 24 hours.  It runs a tad slow right now but that is just one more area we will look to "tweak" in the future.

Amazon CloudSearch is a full-featured and robust search tool and we have only begun to research how to improve functionality. Anyone familiar with CloudSearch technology is welcome to offer assistance in suggesting and implementing improvements.

HH

Toby Lime: Parler...
Posted: 1/19/2021

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  SpiNNy
  First Post Date: 1/18/2021,   Last Post Date: 1/19/2021
Thyroidism Flare up
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dan2341: I take Armour sublingual to get around the no eating window.  Not a great taste!

Posted: 1/19/2021

Toby Lime: TSH is too low... do you experience anxiety, heart palpitations....?
Posted: 1/19/2021

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  Progutforme
  First Post Date: 1/19/2021,   Last Post Date: 1/19/2021
Is a 6 milimeter pulmonary nodule in the lung a serious issu...
Is a 6 milimeter pulmonary nodule in the lung a serious issue? Is it related to diet? Gary’s CT heart scan revealed it. His CT heart scan score is 268. That will come down now with his low carb diet.


  Nanama67
  First Post Date: 1/19/2021,   Last Post Date: 1/19/2021
Is corn starch out...
Is corn starch out

Bob Niland: 
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Nanama67: To oven fry chicken wings. To make crispy 
Posted: 1/19/2021

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  Ilaine
  First Post Date: 6/18/2014,   Last Post Date: 1/19/2021
Apo(E) and Fish Oil

Does APOE Genotype Modify the Relations Between Serum Lipid and Erythrocyte Omega-3 Fatty Acid Levels?

Abstract

Earlier reports indicated that patients with the apolipoprotein APOE ε4 allele responded to fish oil supplementation with a rise in serum low-density lipoprotein cholesterol (LDL-C) compared to ε3 homozygotes. In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Data from 136,701 patients were available to compare lipid biomarker levels across Omega-3 Index categories associated with heart disease risk in all APOE genotypes. We found no adverse interactions between APOE genotype and the Omega-3 Index for LDL-C, LDL particle number, apoB, HDL-C, or triglycerides. However, we did find evidence that ε2 homozygotes lack an association between omega-3 status and LDL-C, apoB, and LDL particle number. In summary, we found no evidence for a deleterious relationship between lipid biomarkers and the Omega-3 Index by APOE genotype.

http://ht.ly/urPvo

From the main paper, which is available free and full, "To the point of this paper, there were no unique relationships between atherogenic lipids and omega-3 status associated with the ε4 genotype."

The effects of omega-3 treatment on lipid profiles in patients carrying an ε4 allele was examined in several previous studies, most from the University of Reading, UK. In the first, despite finding no significant effect of genotype on serum lipid responses to fish oil, the authors stated that, “In APOE4 carriers, the hypotriglyceridemic benefits [of fish oil] may be counteracted by a potential proatherogenic shift in the cholesterol profile” [7]. This conclusion was widely construed by many clinicians to mean that APOE4 carriers should not be given fish oil. A follow-up study reported no effect of genotype, but the dose of omega-3 fatty acids was rather low [9]. In the third study [8], normal volunteers (n = 20 for ε3/ε3 vs. n  = 18 for ε3/ε4) were given either 3.7 g/day of DHA or 3.3 g/day of EPA. The latter had no effect on LDL-C in either group, but the former increased LDL-C by 10 % from baseline in the ε4 carriers compared with a 4 % decrease in the reference group. Of note, apoB was not differentially affected by genotype nor was LDL-P raised by DHA [20]. A 2012 study including 88 subjects failed to confirm the adverse DHA effect [10]. There was no APOE genotype interaction for postprandial lipid responses while on a fish oil diet [21] nor did the authors find a genotype interaction for the effect of fish oil on LDL-C. Our findings, and those from the MESA investigators [12], are consistent with the majority view that the relationship between omega-3 fatty acid blood levels and LDL-C is not different in ε4 carriers relative to that in the common wild-type genotype.
Taking a wider view, it is well known that ε4 patients are at higher risk for CHD [5, 17] and for Alzheimer’s disease [22]. Even if the efficacy of fish oil supplements as treatments for CHD is in question [23, 24], several studies have shown that higher omega-3 fatty acid blood levels are associated with decreased risk for all-cause mortality [2528] and dementia [29]. Direct consumption of EPA and DHA (whether from fish oil supplements or oily fish) is by far the most important determinant of the Omega-3 Index [3033]. Their safety profile is strong [34], and thus, their risk/benefit ratio is favorable. Finally, because ε4 carriers may require higher doses of EPA + DHA to raise the Omega-3 Index (as suggested in some [35, 36] but not other [10] studies), patients carrying this allele may be the most likely to benefit from an increased omega-3 fatty acid intake.

NoMoWheat: Wonder if any more recent studies have been done or is this still applicable?
Posted: 1/19/2021

cpatr922: Very informative, just found out I am E3/E4, will consume higher dosage of fish oils.
Posted: 2/28/2018

Turin: I'm 3/4 and take 1900mg EPA and 1500mg DPA twice daily.  Doing great.  This winter will be 1 year, so I'll be interested to see my blood work when I have it done in December.  Oh yeah, lp(a) here also.
Posted: 8/2/2014


  Ryan
  First Post Date: 1/18/2021,   Last Post Date: 1/19/2021
Heart Disease: rs1333049 Variant - Chromosome 9p21
I recently realized that I have a genetic variation on chromosome 9p21, which poses the highest risk among all genetic variations for developing heart disease (according to mainstream interpretations):

SNP: rs1333049(C;G)

Link to the overall report discussion:
https://innercircle.undoctored.com/forum/topics.aspx?id=25465&PAGE=1#reply-180268

I now have these questions in mind:

- What specific blood markers should I focus on to track the progress? (e.g. TG, or Lp(a)?)

- What specific health measures should I focus on to track the progress? (e.g. CAC score?)

- Is there a specific diet or lifestyle I should follow above and beyond the basics of the program? (e.g. taking more fats, or being more restrictive with carbs?)

- Do I need to make any changes to my supplementation dosage? (e.g. Fish oil ?)

- Although not ideal, could any common medication benefit me over its side effects (e.g. Statins?)

- What has been your experience dealing with this condition if you or someone you know had it too?

- Should I be worried about potentially transferring the condition to a future generation, and is there anything I can do to reduce the risk?

Can someone please link me to a place I can start?

Venkat S: 
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Posted: 1/19/2021

Malcolm: 
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Posted: 1/18/2021

docmaas: Me too.
Posted: 1/18/2021