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MTHFR, Purine Synthesis & Gouty Arthritis
Member Forum >> Arthritis & Joint Pain >> MTHFR, Purine Synthesis & Gouty Arthritis

JennVsDiabesity Join Date: 11/17/2017 Posts Contributed: 921 Total Likes: 99 Recommends Recd: 0 Ignores Issued: 0 Certs & Awards: 0   Likes Recd: 0

Posted: 11/27/2017 12:45:37 PM Edited: 11/27/2017 12:57:47 PM (3)   I am not smart enough yet to read the diagrams of the MTHFR and related pathways and fully understand it, but looking at a few, I see they often mention purine synthesis.  e.g.: https://www.dietvsdisease.org/wp-content/uploads/2015/05/folic-acid-metabolism.png I know excess purines are related to higher levels of uric acid.  Gouty arthritis is something that runs in the family and something I am currently dealing with.  I take 200-300mg of allopurinol per day (depending-- I use a meter every day). I did some google searching on homocysteine and gout and found that gout patients usually have elevated levels of homocysteine, e.g.: https://www.medpagetoday.com/meetingcoverage/eular/20787 I am wondering if there is a relationship between the MTHFR variant that causes mal-absorbtion of folate & b12, and hyperuricemia / gout. I suppose I should get my homocysteine, b12, folate & MMA tested soon.  $112 total at life extension. I am wondering if I do in fact have this MTHFR variant problem, if I correct it with methyl folate, methyl b12 and other b vitamins, if the hyperuricemia might lessen. Tags:

Boo Join Date: 12/17/2009 Posts Contributed: 4798 Total Likes: 1079 Recommends Recd: 10 Certs & Awards: 0   Likes Recd: 0

Posted: 11/27/2017 1:46:35 PM Back to Top   https://articles.mercola.com/gout/causes.aspx Tags:

Dr. Davis Inner Circle Staff Join Date: 12/20/2007 Posts Contributed: 10967 Total Likes: 2346 Recommends Recd: 15 Certs & Awards: 0   Likes Recd: 1

Posted: 11/27/2017 1:54:37 PM Back to Top   Reply Content Hidden! Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!). Sign Up Today! Tags:

JennVsDiabesity Join Date: 11/17/2017 Posts Contributed: 921 Total Likes: 99 Recommends Recd: 0 Certs & Awards: 0   Likes Recd: 0

Posted: 11/27/2017 2:12:29 PM Edited: 11/27/2017 2:27:11 PM (1) Back to Top   Reply Content Hidden! Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!). Sign Up Today! Tags:

JennVsDiabesity Join Date: 11/17/2017 Posts Contributed: 921 Total Likes: 99 Recommends Recd: 0 Certs & Awards: 0   Likes Recd: 0

Posted: 11/27/2017 2:29:17 PM Edited: 11/27/2017 2:35:52 PM (4) Back to Top   Reply Content Hidden! Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!). Sign Up Today! Tags:

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JennVsDiabesity Join Date: 11/17/2017 Posts Contributed: 921 Total Likes: 99 Recommends Recd: 0 Certs & Awards: 0   Likes Recd: 0

Posted: 11/28/2017 2:48:41 PM Edited: 11/28/2017 3:06:20 PM (12) Back to Top   Reply Content Hidden! Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!). Sign Up Today! Tags:

Dr. Davis Inner Circle Staff Join Date: 12/20/2007 Posts Contributed: 10967 Total Likes: 2346 Recommends Recd: 15 Certs & Awards: 0   Likes Recd: 1

Posted: 11/28/2017 4:13:24 PM Back to Top   Very instructive observations, Jenn! Tags:

Boo Join Date: 12/17/2009 Posts Contributed: 4798 Total Likes: 1079 Recommends Recd: 10 Certs & Awards: 0   Likes Recd: 1

Posted: 11/29/2017 1:11:26 AM Edited: 11/29/2017 1:12:19 AM (1) Back to Top   Reply Content Hidden! Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!). Sign Up Today! Tags:

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Posted: 11/29/2017 9:10:44 AM Back to Top   Boo, What is box breathing? Tags:

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JennVsDiabesity Join Date: 11/17/2017 Posts Contributed: 921 Total Likes: 99 Recommends Recd: 0 Certs & Awards: 0   Likes Recd: 0

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Posted: 11/29/2017 9:05:27 PM Edited: 11/30/2017 11:20:02 AM (1) Back to Top   Reply Content Hidden! Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!). Sign Up Today! Tags:

JennVsDiabesity Join Date: 11/17/2017 Posts Contributed: 921 Total Likes: 99 Recommends Recd: 0 Certs & Awards: 0   Likes Recd: 2

Posted: 11/29/2017 11:51:24 PM Edited: 11/30/2017 12:34:05 AM (6) Back to Top   Reply Content Hidden! Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!). Sign Up Today! Tags: