Two SNPs from chromosome 4q25, rs2200733 and rs10033464, were found to be associated with atrial fibrillation in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x.[PMID 17603472]

[PMID 18931155] The results derived from a study of 78 Italians with atrial fibrillation (AF) and atrial flutter (AFL) agree with previously reported findings from the Icelandic study ([PMID 17603472]), which also found that the rs2200733(T) was associated with AF/AFL disease.

[PMID 18991354] In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, rs2200733 was associated with cardioembolic stroke (CES) (odds ratio 1.54, p = 8.05 x 10e-9). rs2200733 even showed association to ischemic stroke that was not classified as cardioembolic stroke.

[PMID 19141561] rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.