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Aspirin isn't recommended for atrial fibrillation patients

Member Forum >> UnKnown >> Aspirin isn't recommended for atrial fibrillation patients

searcher7

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Posted: 7/1/2014 3:22:29 AM
 
In a video interview at Heart Rhythm 2012, Dr. Albert Waldo, one of the world’s foremost atrial fibrillation treatment experts, discusses why aspirin no longer plays a role in stroke prevention in atrial fibrillation and how aspirin has already been removed from various guidelines around the world. He cites that numerous studies have found aspirin to be no better than a placebo, and to have greater bleeding risks than the newer anticoagulants. The new drugs have even shown that they’re not only more effective than aspirin, but that they have less bleeding [Dabigatran (Pradaxa) ,Rivaroxaban (Xarelto) ,Apixaban (Eliquis) ].

http://www.stopafib.org/newsitem.cfm/NEWSID/412/Dr-Albert-Waldo/aspirin-not-effective-for-atrial-fibrillation-stroke-prevention   Patients who are taking aspirin solely for this purpose should be reviewed.RCPE UK Consensus Conference on 'Approaching the comprehensive management of Atrial Fibrillation: Evolution or revolution?', Royal College of Physicians of Edinburgh (RCPE), March 2012.


A cardiologist or an electrophysiologist  should recommend what each patient should do.

1) A patient who only has an occasional epsisode of atrial fibrillation  may be able to take the pill in the pocket approach. For example they could take Flecainide tablets when atrial fibrillation occurs and take Pradaxa capsules  for a short time to prevent clot formation.
2) A patient who has frequent episodes may have to take medication all the time to prevent atrial fibrillation and take one of the newer anticoagulants all the time. The most commonly used anti-arrhythmic drugs are flecainide, amiodarone, propafenone, disopyramide and dronedarone.

3) Left atrial appendage closure

Attached to the top left chamber of the heart (the left atrium) is a "pocket" which is called the left atrial appendage. Although blood clots in the heart can sometimes form in the top chambers of the heart (the atria), in 9 out of 10 cases they occur in this "pocket" (the left atrial appendage). It is possible to close or block the entrance between the top left chamber of the heart and this pocket (the left atrial appendage), by using a special device called a left atrial appendage closure device. This device is fitted during an operation. Some devices are fitted inside the pocket, and involve special thin flexible tubes (electrodes) being passed into your heart through a blood vessel, usually in your groin or neck, and then the device is inserted into your heart through these tubes. Other devices are fitted on the outside of this pocket during a surgical procedure.

Not every patient is suitable for a left atrial appendage closure device. This device is not usually considered as the first treatment option to try to reduce the risk of stroke in patients with atrial fibrillation. The main treatment option for reducing the risk of stroke in the majority of people with atrial fibrillation is a blood-thinning medicine (an anticoagulant). The left atrial appendage closure device may be an alternative treatment option if you are not able to take any of the blood-thinning medicines, usually because of a very high risk of bleeding. Several different left atrial appendage closure devices are available and your doctor will discuss the available options if this type of device is a suitable treatment option for you.

 The operation required to fit a left atrial appendage closure device carries some important risks. These risks include: (1) problems placing the device properly because the "pocket" is not the same shape and size in every patient; (2) a small hole needs to be made to pass the device from the right side of heart to the left side of the heart and sometimes (but rarely) this can lead to serious bleeding; (3) blood clots forming in the device; and (4) death. This operation is carried out by a specialist heart doctor who is experienced at doing these procedures.

You will need to take aspirin or a blood-thinning medicine for at least 6 weeks after having this device fitted. Aspirin can increase the risk of serious bleeding. In addition, only 9 out of 10 blood clots are formed in the left atrial appendage (pocket) and therefore having this device fitted does not completely remove the risk of stroke. Depending on your risk of stroke you may need to continue taking a blood-thinning medicine after you have had the device fitted.

The left atrial appendage in the left atrium is one of the areas in which blood is more likely to pool during atrial fibrillation, which can lead to the development of a blood clot. Several new procedures make it possible to close off blood flow to and from this part of the heart. A special device can be inserted using a catheter placed in the left atrium, then the catheter is removed and  the device is left in place in the left atrial appendage. Other devices are applied to the outside of the left atrial appendage during surgical procedures.

Not every patient is suitable for a left atrial appendage closure device.  These devices arenot usually considered as the first treatment option to try to reduce the risk of stroke in patients with atrial fibrillation.  The main treatment option for reducing the risk of stroke in the majority of people with atrial fibrillation is a blood-thinning medicine (an anticoagulant).  The left atrial appendage closure device may be an alternative treatment option if you are not able to take any of the blood-thinning medicines, usually because of a very high risk of bleeding.  http://www.afibmatters.org/Treatments

4) Catheter Ablation

The aim of this procedure, called a catheter ablation, is to electrically isolate the areas of the heart that are causing the abnormal electrical activity. This can be achieved  either by burning (”radiofrequency ablation”) or freezing (“cryoablation”) the heart cells that serve as an electrical trigger and causeatrial fibrillation. In some people, this procedure can "cure" their atrial fibrillation. Depending on which area or areas of the heart are the site(s) of the faulty electrical signals, different areas can be "ablated".

Catheter ablation is an invasive procedure which means that special thin flexible tubes (electrodes) are passed into your heart through a blood vessel, usually in your groin. This is done in hospital and in most cases you  will need to stay in hospital for  one or two days. Before beginning this test some medications are given to numb the skin over the blood vessels used (local anesthesia) or by putting you to sleep (general anesthesia or deep sedation).

5) Pacemaker

Some patients who have both atrial fibrillation and a low heart rate may need to have a pacemaker fitted. Pacemakers are small electronic devices that are placed (implanted) under the skin just below your collarbone. Pacemakers are usually used when your heart's own electrical system fails to generate enough signals to ensure a good heart rate. Pacemakers are not effective to treat atrial fibrillation in itself. Not everyone who has atrial fibrillation will need a pacemaker implanted.

http://www.afibmatters.org/Treatments
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I saw a cardiologist about my atrial fibrillation which was brought about by taking metoprolol once a day instead of twice a day. He said he had only lost one patient  on warfarin therapy and that was from bleeding. He said patients  and cardiologists don't like
warfarin any more because of the necessity to have blood samples taken and tested regularly. It's hard to manage. One of the new anticoagulants is preferred. Pradaxa is supposed to be 35% more effective than warfarin.

The drawback with the new anticoagulants is that there is no antidote (reversal agent ) if excessive GI bleeding is caused by the anticoagulant. Some older patients are being switched from Pradaxa to Xarelto if sensitive to bleeds from Pradaxa. The cardiologist said there was a way to stop the bleeding but he didn't elaborate.

Researchers have been working on the development of antidotes which should be on the market later in 2014.One example is an antidote for Pradaxa.

Boehringer Ingelheim announced that the FDA has granted Breakthrough Therapy designation to idarucizumab, an investigational fully humanized antibody fragment (Fab), being evaluated as a specific antidote for Pradaxa (dabigatran etexilate mesylate).

Data from a Phase 1 trial demonstrated that idarucizumab was able to achieve immediate, complete, and sustained reversal of dabigatran-induced anticoagulation in healthy humans. The on-set of action of the antidote was detected immediately following a 5-minute infusion while thrombin time was reversed with idarucizumab. Reversal of the anticoagulation effect was complete and sustained in 7 of 9 subjects who received the 2g dose and in 8 out of 8 subjects who received the 4g dose. The 1g dose resulted in complete reversal of anticoagulation effect; however, after approximately 30 minutes there was some return of the anticoagulation effects of dabigatran.

The cardiologist I consulted said aspirin was a ' weak option '. He also said fish oil wouldn't prevent a stroke in someone who has atrial fibrillation.







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lindybill

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Posted: 7/1/2014 6:27:40 AM
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Not needed for Afib but how about for CAD?


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jaxrph

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Posted: 7/1/2014 7:21:36 AM
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They are going to anticoagulate every person walking the earth before they are through.  Note: aspirin is antiplatelet.
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searcher7

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Posted: 7/2/2014 8:31:43 PM
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lindybill

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Posted: 7/2/2014 9:35:41 PM
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Posted: 7/2/2014 11:59:27 PM
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harry35

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Posted: 7/3/2014 8:01:45 AM
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Posted: 7/4/2014 1:52:08 PM
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Posted: 6/22/2016 8:14:56 AM
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