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What causes heart disease part XXXIV (part thirty-four)

Inner Circle Member Forum >> Food and Diet >> What causes heart disease part XXXIV (part thirty-four)

xtronics

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Posted: 8/12/2017 1:08:32 PM
Edited: 8/12/2017 1:10:16 PM (1)
 
Undoctored is mentioned many times in the comments..

Malcoms latest


I think he has the understanding of epistemology wrong - one first has to see the difference between observational studies and experimental science.  Then the bit about correlation are not causation - direction of causation matters.  At least one one else has picked up on the bit that LDL is not a ’thing’  but only a class of things..  Looking at correlations in a system as complex as our bodies is just not very useful - at best it tells us where we might try a controlled experiment. There is some good  low level science  to do with macrophage receptors - and some patterns - but way to much ego driven narrative.


If you reduce LDL with several drugs and it has no effect on all-cause-mortality - then it falsifies the idea that LDL CAUSES CAD.


But in my mind it is even a bit more complex - there is a cause of the initial damage - ( likely suspects insulin/stress - other cofactors ) - but once the damage is there - managing the clot potential seems to matter...  And that is where keeping oxLDL low seems a good bet..

,.,.

The problem is one of the methods - using polyphenols - is not clear cut - I found that using a mix of polypheol supplements interfered with strength training.  Digging up studies and others have seen the same thing..

So IMO polyphenols in excess are likely harmful - and we don’t have the research to base sane dosages on.

I’m back to eating real food - using spices that have polyphenols in them - I don’t think there is a real need for the supplements if one eats real-foods and avoids the synthetic-foods(purified veg-oils, chips, almond-milk or any juices, things that come in boxes, things with more than a couple of ingredients)

Interventions of elimination are much less likely to have risk than interventions of addition. Purified anything,

 

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Medford

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Posted: 8/12/2017 4:41:18 PM
 
Is this Malcolm, the forum Malcolm?




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xtronics

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Posted: 8/12/2017 7:03:17 PM
 
@Medford   no no --- it is  Dr. Malcolm Kendrick  -- author of the "what causes hear disease" blog series..  quite interesting.



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